PREPARE WEBINARS

A series of 5 topical webinars

17 March 2021 – 14 April 2021

About the event

Many ground-breaking research studies, data analyses, reviews and surveys have been performed under the umbrella of PREPARE. To celebrate the end of PREPARE and showcase the many achievements of the project to the outside world, we are launching a series of five webinars that will be held every Wednesday at 14:00 CET from 17 March to 14 April. Topics will include the MERMAIDS trials, clinical epidemiology, diagnostics algorithms, public and patient involvement in pandemic preparedness, outcomes from the REMAP-CAP flu domain, Health Economics, and many others.

The webinar on 14 April is specifically addressed to policy makers and will highlight the work of PREPARE and RECOVER, the lessons learned from the COVID-19 pandemic, the barriers for clinical trials, and the future of clinical research in Europe.

 

Event booklet

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PREPARE newsletters

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Webinars Recordings

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Programme

The programme comprises sessions and keynote lectures to present PREPARE’s research data and achievements.

FIRST WEBINAR: A MERMAIDS Tale: Acute Respiratory Infections

Wednesday 17 March 2021

Moderator: Menno de Jong (AMC Amsterdam)

MERMAIDS is the Multi-centre EuRopean study of MAjor Infectious Disease Syndromes. In this webinar we will take you on a journey of exploring the reasons as to why some people with acute respiratory infections become more unwell than others. Can the expression of specific genes tell us why some people go on to develop more severe disease and is this related to other clinical features such as comorbidity and type of infection? And are clinical risk factors different in children? To our knowledge, these are the largest studies of this type ever done and for the first time, we will be presenting this data and telling this story.

Programme
14:00 CET
Welcome by the moderator
14:00 - 14:05
A MERMAIDS tale - by Peter Horby (University of Oxford)
14:05 - 14:20
Once upon a time: There was one of the largest transcriptomic studies on Acute respiratory Infections - by James Lee (University of Oxford) and Louise Sigfrid (University of Oxford)
14:20 - 14:45
Myth of truth? Profiling host gene expression during acute respiratory infections - by Cosimo Cristella (AMC Amsterdam)
14:45 - 15:00
More than a children's story: Aetiology and management of paediatric ARI hospitalisations - by Malte Kohns (University of Düsseldorf)
15:00 - 15:30
Questions & Answers

SECOND WEBINAR: ARBOVIRUSES STUDIES

Wednesday 24 March 2021

Moderator : Marion Koopmans (Erasmus MC) + Corneliu Popescu (Carol Davila University of Medicine and Pharmacy)

This webinar focuses on arboviruses in Europe, presenting data from experiences of annual outbreaks of West Nile virus in Romania, and an overview of the results from the PREPARE MERMAIDS Arbovirus, seasonal observational study set in hospital sites in seven countries across southeast Europe from May 2016 to January 2020.

Programme
14:00 CET
Welcome by the moderator
14:00 - 14:15
Experiences with West-Nile in Romania - by Corneliu Popescu (Carol Davila University of Medicine and Pharmacy)
14:15 - 14:30
Arboviruses observational research outcomes - by Louise Sigfrid (University of Oxford)
14:30 - 14:45
Arbovirus diagnostics, the serology nightmare - by Erwin de Bruin (Erasmus MC)
14:45 - 15:00
Connecting with other emerging diseases research - by Marion Koopmans (Erasmus MC)
15:00 - 15:30
Questions & Answers

THIRD WEBINAR: PREPARING FOR AN INFLUENZA PANDEMIC

Wednesday 31 March 2021

Moderator: Peter Openshaw (Imperial College London)

The world has been astonished by the impact of the COVID-19 pandemic, which we all hope to see defeated by the application of top-level science of the type promoted by the PREPARE consortium. In this session, we will provide a top-level overview of just what can be achieved in preparing for the next pandemic and just how important it is that we maintain our science base in readiness for future pandemics. We will focus on influenza, a likely cause of future pandemics, but the messages from this session have broad application in relation to other viral outbreaks. We will demonstrate the potential of human challenge studies to discover key facts about the host response to infection, the studies that are being performed to find new treatments both for mild and severe disease and, importantly, how these advances benefit from public engagement and can be made relevant policymaking.

Programme
14:00 CET
Welcome by the moderator
14:00 - 14:15
Outcomes of human challenges studies and transcriptomics - by Chris Chiu (Imperial College London) and Menno de Jong (AMC Amsterdam)
14:15 - 14:30
ITU therapeutic studies in influenza (REMAP-CAP) - by Lennie Derde (UMC Utrecht)
14:30 - 14:45
Health economics and cost-effectiveness of therapy - by Philippe Beutels (University of Antwerp) and Chris Butler (University of Oxford)
14:45 - 15:00
Public and patient involvement in pandemic preparedness - by Alistair Nichol (University College Dublin)
15:00 - 15:30
Questions & Answers

FOURTH WEBINAR: WHY FUTURE CLINICAL TRIALS WILL BE PLATFORM TRIALS

Wednesday 7 April 2021

Moderator & co-moderator: Lennie Derde (UMC Utrecht) + Marc Bonten (UMC Utrecht)

The COVID-19 pandemic changed the way of performing clinical therapeutic research. The platform trial REMAP-CAP proved to be highly efficient and provided evidence-based guidance for treatment of patients hospitalized with COVID-19. Platforms clearly represent the future of clinical trials. In this session the beauty, complexity and results from the REMAP-CAP trial will be presented, complemented by the description of yet another new platform trial for evaluating COVID-19 treatment in primary care.

Programme
14:00 CET
Welcome by the moderator
14:00 - 14:15
Platform trials: the beauty of the beast - by Derek Angus (University of Pittsburgh)
14:15 - 14:30
Finding your inner Bayesian - by Scott Berry (Berry Consultants)
14:30 - 14:45
The PRNCIPLE Platform Trial for COVID-19 in the community: Taking research to patients - by Chris Butler (University of Oxford)
14:45 - 15:00
REMAP-CAP: the beast unleashed - by Lennie Derde (UMCU)
15:00 - 15:30
Questions & Answers

FIFTH WEBINAR: SEVEN YEARS OF PREPARE: key outcomes and the way forward

Wednesday 14 April 2021

Moderator & co-moderator: Herman Goossens (University of Antwerp) and Jeremy Farrar (Wellcome Trust)

After seven years of PREPARE it is time to look back. Many ground-breaking research studies, data analyses, reviews and surveys have been performed under the umbrella of the PREPARE and also RECOVER in their research response to the COVID-19 pandemic. It is important to take a look at what we have achieved, and especially what can we learn from it. And finally, we also look ahead by sharing our vision of a sustainable clinical research in Europe through ECRAID, a European-wide initiative with the goal of establishing a single-access clinical research network for infectious diseases.

Programme
14:00 CET
Welcome by the moderator
14:00 - 14:15
Highlights of PREPARE and RECOVER, lessons learned and Pandemic preparedness after COVID-19 - by Herman Goossens (University of Antwerp)
14:15 - 14:30
Rapid deployment of clinal research in public health emergencies - by Nina Gobat (University of Oxford)
14:30 - 14:45
Diagnostic preparedness: where we stand now - by Marion Koopmans (Erasmus MC)
14:45 - 15:00
The future of clinical research in Europe: ECRAID - by Marc Bonten (UMC Utrecht)
15:00 - 15:30
Questions & Answers

Contact us

For more information, please contact David De Pooter